{
  "study_id": "NCT05047120",
  "agent": "baseline",
  "run": 1,
  "p_primary_hypothesis_supported": 0.68,
  "effect_direction": "favours intervention",
  "effect_size_90pct_interval": {"low": -0.2, "high": 2.0, "metric": "Between-arm difference in 0-10 NRS pain change (positive = more pain reduction with HYP-CT)"},
  "moderator_prediction": "Higher-baseline-pain patients show larger within-session decreases (more room to fall); neuropathic vs nociceptive difference likely small, with a slight edge for nociceptive/musculoskeletal pain, which is more responsive to relaxation and suggestion.",
  "claim_ids_used": [],
  "rationale": "The first primary outcome is the immediate pre-post session pain drop. Hypnosis with direct analgesic suggestions reliably produces short-term self-reported pain reduction (g about 0.5-0.75 in experimental pain; about 0.35 for procedures), while education sessions offer little immediate analgesia. Repeated measures (8 sessions per patient, n=88) give reasonable power for the within-session contrast, and patients are unblinded, which favours self-report. Risks: small sample, attrition in inpatient rehab, an interactive education comparator with some nonspecific relief, and the report possibly making 4-week average pain primary, where the effect would be smaller and likely null. Expect about 0.8 NRS points more within-session reduction with HYP-CT."
}