{
  "study_id": "NCT05047120",
  "agent": "baseline",
  "run": 5,
  "p_primary_hypothesis_supported": 0.6,
  "effect_direction": "favours intervention",
  "effect_size_90pct_interval": {"low": -0.2, "high": 1.8, "metric": "Between-arm difference in 0-10 NRS pain change (positive = more pain reduction with HYP-CT)"},
  "moderator_prediction": "Higher-baseline-pain patients show larger immediate HYP-CT reductions (more room to fall, regression to the mean); neuropathic vs nociceptive difference likely small or not detectable at n=88. Highly hypnotisable patients respond more.",
  "claim_ids_used": [],
  "rationale": "First primary is the immediate pre-post session pain drop, a short-term self-reported outcome where hypnotic analgesia is most reliable (g ~0.5-0.75 experimental; ~0.35 procedural). Repeated measures across ~4 sessions per patient add power despite n=88. Comparator is an attention-matched, interactive pain-education session with a psychologist, which also yields some within-session relief, shrinking the gap. Unblinded participants and self-report favour a positive result. Risks: modest sample, attrition during inpatient stay, and possible designation of 4-week average pain (chronic, smaller effect, likely null) as primary. Net slightly above coin flip."
}