{
  "study_id": "NCT05047120",
  "agent": "framework",
  "run": 1,
  "p_primary_hypothesis_supported": 0.68,
  "effect_direction": "favours intervention",
  "effect_size_90pct_interval": {"low": 0.1, "high": 1.9, "metric": "Between-arm difference in 0-10 NRS pain change (positive = more pain reduction with HYP-CT)"},
  "moderator_prediction": "Higher-baseline-pain patients show larger session-level reductions (more room, higher arousal/attention); nociceptive and neuropathic both respond acutely, with neuropathic pain less durable because daily sensation contradicts the suggestion more often.",
  "claim_ids_used": ["PM-0023", "PM-0369", "PM-1286", "PM-0232", "PM-0092", "PM-0128", "PM-0333", "PM-0137", "PM-0146"],
  "rationale": "The primary is an immediate pre-post session pain change: a render-layer outcome measured right after an induction that suspends the critical faculty, the framework's strongest case (PM-0023, PM-0369, PM-1286). A PhD hypnotist in a hospital room adds authority (PM-0232); a saturated session books heavily regardless of count (PM-0092). Pain education is propositional, paying the normal tax (PM-0128), so acute relief should be smaller. Recordings give a conditioned re-entry cue (PM-0333). Risks: active comparator with the same therapist attention, n=88 split, multiple co-primaries, and the 4-week weekly-average outcome being decisive instead, where daily contradiction and starvation shrink effects (PM-0137, PM-0146)."
}