{
  "study_id": "NCT06632691",
  "agent": "framework",
  "run": 1,
  "p_primary_hypothesis_supported": 0.45,
  "effect_direction": "favours intervention",
  "effect_size_90pct_interval": {"low": -0.3, "high": 2.0, "metric": "Mean difference in VAS pain, 0-10 (positive = less pain with the headset)"},
  "moderator_prediction": "Anxious patients benefit more: threat-primed receivers price the procedure's pain signals heaviest, so a hypnotic state change that captures attention has more to remove; sex difference expected to be small.",
  "claim_ids_used": ["PM-0023", "PM-0369", "PM-1286", "PM-1340", "PM-0132", "PM-0092", "PM-0485", "PM-0845", "PM-0159", "PM-0232", "PM-0361"],
  "rationale": "VR hypnosis is a state change and backdoor past the critical faculty (PM-1340, PM-0023, PM-0369), aimed at a render-layer outcome, felt pain, which the framework says belief reaches (PM-1286). Immersive setting and captured attention raise impact within one session (PM-0092, PM-0485). Unmasked self-report lets the Prover read ambiguous sensation as relief (PM-0159). Against that, a headset replaces live hypnotist authority and rapport (PM-0232, PM-0361), rectosigmoidoscopy is brief and only mildly painful (floor effect), and n=100 has power only for about 1.3+ VAS points. Expected difference about 0.8-1 point, so significance is roughly a coin flip, slightly below. Anxious patients should gain most (PM-0845)."
}