{
  "study_id": "NCT06632691",
  "agent": "framework",
  "run": 3,
  "p_primary_hypothesis_supported": 0.5,
  "effect_direction": "favours intervention",
  "effect_size_90pct_interval": {"low": -0.3, "high": 2.0, "metric": "Mean difference in VAS pain, 0-10 (positive = less pain with the headset)"},
  "moderator_prediction": "Anxious patients benefit more: fear raises the weight of threat signals and the hypnotic bypass removes more of that pricing; no clear sex difference beyond anxiety.",
  "claim_ids_used": ["PM-0023", "PM-0369", "PM-1286", "PM-0086", "PM-0132", "PM-0230", "PM-0845", "PM-0601", "PM-0314", "PM-0159", "PM-0216"],
  "rationale": "The framework treats hypnosis and musical trance as backdoors that write at the render layer, where pain lives, so it predicts less felt pain with the headset. Unmasked, self-rated pain recalled right after the procedure favours the belief of the arm the patient was in. Against this: patients already know rectosigmoidoscopy from prior exams (a deep incompatible expectation), baseline pain is modest (floor effect), a single brief induction with an alert, observed patient offers only a shallow bypass, and 50 per arm gives limited power for a difference near 1 point. Expected difference is about 0.8-1.0 VAS points, and whether it reaches significance is close to a coin flip."
}