{
  "study_id": "NCT06632691",
  "agent": "framework",
  "run": 4,
  "p_primary_hypothesis_supported": 0.55,
  "effect_direction": "favours intervention",
  "effect_size_90pct_interval": {"low": -0.3, "high": 2.0, "metric": "Mean difference in VAS pain, 0-10 (positive = less pain with the headset)"},
  "moderator_prediction": "Anxious patients benefit more: arousal raises the weight of both the threat render and the hypnotic counter-render, so the induction has more to reprice; sex difference small or none.",
  "claim_ids_used": ["PM-0023", "PM-0369", "PM-1340", "PM-1286", "PM-0230", "PM-0403", "PM-0159", "PM-0601", "PM-0137"],
  "rationale": "VR hypnosis is a state change that suspends the critical faculty (PM-1340, PM-0023, PM-0369), with immersive sound and setting as backdoors (PM-0230, PM-0403), aimed at a render-layer outcome, felt pain (PM-1286). Unblinded self-report lets the Prover read ambiguous sensations favourably (PM-0159), all favouring the headset. Against: rectosigmoidoscopy is short and only mildly painful, compressing the VAS; patients are experienced, so the prior 'this hurts' is installed and must be outspent (PM-0137); n=100 gives roughly 50-60% power for a 1-point difference. Anxious receivers price more heavily (PM-0601). Expected difference about 0.8-1.0 point; significance is near a coin flip, slightly favoured."
}