{
  "study_id": "NCT06632691",
  "agent": "framework",
  "run": 5,
  "p_primary_hypothesis_supported": 0.45,
  "effect_direction": "favours intervention",
  "effect_size_90pct_interval": {"low": -0.3, "high": 2.0, "metric": "Mean difference in VAS pain, 0-10 (positive = less pain with the headset)"},
  "moderator_prediction": "Anxious patients benefit more: arousal amplifies the pricing of procedural threat, so a hypnotic render that absorbs attention removes more pain from them; sex difference likely none.",
  "claim_ids_used": ["PM-1286", "PM-0023", "PM-0369", "PM-0372", "PM-0092", "PM-0159", "PM-0845", "PM-0601", "PM-0126"],
  "rationale": "Pain is a render-layer outcome, the level the framework says hypnosis and absorbed attention reach (PM-1286, PM-0023, PM-0369, PM-0372); an immersive saturated session outweighs duration (PM-0092). Unmasked, self-rated VAS lets the installed 'this helped' belief colour the report (PM-0159), favouring the headset. But VR hypnosis is a single weak backdoor without live hypnotist authority (PM-0126), rectosigmoidoscopy pain is modest (floor effect), patients are experienced with the exam, and ~50 per arm gives power only for about 1+ point. Prior endoscopy VR trials are mixed. Expect a modest reduction (~0.8 points), borderline significance. Anxious, aroused receivers price threat higher and gain more (PM-0845, PM-0601)."
}